Yang kq, yang yk, meng x, zhang y, zhang hm, wu hy, et al. Takayasu s arteritis is a chronic systematic inflammatory disease. Aortic valve replacement surgery for a case of infantile takayasu arteritis. Itas2010 was significantly higher in patients with active disease. A chronic inflammatory process that affects the aorta and its primary branches, such as the brachiocephalic artery brachiocephalic trunk and carotid arteries. Assessment of disease activity and progression in takayasus. Takayasus arteritis ta is a rare primary and granulomatous largevessel vasculitis of unknown origin predominantly affecting the aorta and its major division branches. Aug 11, 2011 takayasu arteritis is an autoimmune vasculitis that affects the large and medium vessels. Takayasus arteritis is a rare, idiopathic, chronic inflammatory disease with cellmediated inflammation, involving mainly the aorta and its major branches. Takayasus arteritis is a chronic vasculitis of unkown origin. The aorta and its branches are mainly involved and stenosis or. Although originally believed to be a disease mostly affecting young women of asian descent since its original description in japan by takayasu, kagoshima and onishi at the beginning of the 20th century, ta.
Takayasu s arteritis ta is a rare, chronic panarteritis of the aorta and its major branches presenting commonly in young ages. Takayasus arteritis symptoms and causes mayo clinic. Takayasus arteritis overlapping with systemic sclerosis clin exp. Information for patients with takayasu s arteritis. Takayasus arteritis associated with tuberculosis infections abstract. Takayasu described the retinal changes of the disease in 1905 at the annual ophthalmology society meeting in japan, and his abstract was subsequently published in 1908. An unknown stimulus triggers the 65 kda heatshock protein expression in the aortic tissue which, in turn, induces the major histocompatibility class i chainrelated a mica on vascular cells. Cv rr 70 cpm, ruidos alejados, soplo holodiastolico en foco aortico. It results in progressive arterial stenosis, occlusion, and aneurysm formation. Takayasus arteritis is a form of vasculitis inflammation of the blood vessels that damages the large arteries, especially the aorta.
Takayasu arteritis has been associated with different human leucocyte antigen hla alleles in different populations. Takayasu arteritis ta is a rare form of large vessels vasculitis of unknown etiology, which occurs most. Although all large arteries can be affected, the aorta, subclavian and carotid arteries are most commonly involved 6090% 2, 3. Familial takayasu arteritis a pediatric case and a.
Takayasus arteritis ta is an inflammatory disease of unknown etiology. Takayasu arteritisadvances in diagnosis and management. Takayasu s arteritis is a rare, idiopathic, chronic inflammatory disease with cellmediated inflammation, involving mainly the aorta and its major branches. Clinical features and diagnoses of takayasu arteritis. Limitations of therapy and a guarded prognosis in an american cohort of takayasu arteritis patients. To assess the indian takayasu clinical activity score itas2010 in followup of takayasu arteritis ta. The first case corresponds to a young woman who met the american college of rheuma tology criteria for takayasu arteritis. Isolated ta of pulmonary artery branches is very rare. Ta is a form of granulomatous panendarteritis resulting in occlusion and thrombosis of the aorta and pulmonary arteries. Takayasu arteritis ta is a rare chronic inflammatory disease of the aorta and its major branches.
Assessment of disease activity and progression in takayasu. Assessment of patients with takayasu arteritis in routine. Vasculitis is uncommon, and large or median vessel vasculitis, such as takayasu and temporal arteritis, are even more. Updates in pathophysiology, diagnosis and management of takayasu arteritis. Clinical activity was assessed with physicians global assessment pga and criteria defined by kerr, et al. The american college of rheumatology 1990 criteria for the. Table 3 presents the definitions for the 6 criteria selected. Takayasu arteritis is a granulomatous vasculitis which mainly. The disease results from an attack by the bodys own immune system, causing inflammation in the walls of arteries. Takayasuss arteritis ta is a chronic, inflammatory.
To date, familial cases of ta have been considered rare. Physical examination findings, presence of constitutional features, elevated acutephase reactants, and new vessel involvement in imaging are major features of an active disease. Takayasus arteritis ta is a rare, chronic panarteritis of the aorta and its major branches presenting commonly in young ages. Pentraxin3 as a marker of disease activity in takayasu arteritis.
It is seen predominantly in females during the second and third decades of life, although it can occur in childhood. Abstract we describe the case of a 28yearold woman who presented to our clinic with a history of chronic bilateral visual loss and recent episodes of syncope. One criterion, aortic murmur, had poor sensitivity 32. Typical angina in a patient with takayasu arteritis hanson. Takayasu aortoarteritis is a rare, chronic granulomatous panarteritis with significant morbidity amongst young patients. There were twenty male cases, 53 female cases of 73 patients with takayasu arteritis, the ratio of male to female was 1. Endovascular aortic biopsy in the diagnosis of takayasu arteritis. New tools for disease assessment such as indian takayasu arteritis score itas2010 and. Arterial stenosis, occlusion, and aneurysms lead to various signs and symptoms such as extremity pain, claudication.
566 799 465 1225 1158 1260 779 904 105 1342 768 1260 740 431 458 1280 194 91 1299 79 1213 789 890 1217 913 1308 433 111 1376 1121